Glucose-6-phosphate dehydrogenase (G6PD) is verified to be an independent risk factor related to the adverse outcomes of HCC, and exacerbates tumor growth, invasion, and metastasis, along with reduced ferroptosis through suppressing cytochrome P450 oxidoreductase (POR) (Cao et al., 2021). This evidence concerns the gene G6PD and hepatocellular carcinoma.