For instance, ABCC5 (ATP binding cassette subfamily C member 5), highly expressed in sorafenib-resistant HCC cells, elevates GSH and alleviates lipid peroxidation by stabilizing SLC7A11, thus leading to suppression of ferroptosis and inducing the resistance to sorafenib (Huang et al., 2021). This evidence concerns the gene SLC7A11 and hepatocellular carcinoma.