Wan et al. (2022) screen 5 ferroptosis-related markers [G6PD, HMOX1 (heme oxygenase 1), LOX (lysyl oxidase), SLC7A11, and STMN1 (stathmin 1)], which are associated with higher tumor-node-metastasis stage, cirrhosis and immunosuppressive microenvironment in tumor tissue, and further well predict the prognosis of HCC. Studies have found that ferroptosis-related genes serve as independent risk factors to evaluate the clinical efficacy of chemotherapy and immunotherapy in HCC (Gao R. et al., 2021; Xiong et al., 2022). This evidence concerns the gene LOX and hepatocellular carcinoma.