Therefore, combination DHA and sorafenib has a synergistic inhibitory effect on HCC cells by attenuated energy metabolism and potent ferroptosis, which is evident by increased levels of lipid ROS, iron and MDA, as well as reduced expression of GSH, SLC7A11 and GPX4 (Cui et al., 2022). This evidence concerns the gene GPX4 and hepatocellular carcinoma.