CD274 and neoplasm: A recent study has unveiled that knockout of SLC7A11, a ferroptosis-related gene, in macrophage reduces the recruitment and infiltration of tumor-associated macrophages by activating ferroptosis, which elevates PD-L1 expression in macrophages and improves the antitumor efficacy of anti-PD-L1 therapy (Tang B. F. et al., 2023).