Given the crucial role of the osteoprotegerin (OPG)-receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL) system in the development of CN (Bruhn-Olszewska et al., 2017), bone metabolism was considered to be actively involved in the pathological alteration of CN. Here, TNFSF11 is linked to cyclic hematopoiesis.