This result was in accordance with the report that HDACi, such as SAHA and LAQ824, were shown to inhibit BCR-ABL expression at both the mRNA and protein level in CML cells, paralleled by the increased acetylation of histone H3 levels (Nimmanapalli et al., 2003a; Nimmanapalli et al., 2003b). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.