ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Additionally, it was reported that transient silencing of BCR-ABL or BCR-ABL deficiency can induce the differentiation of CML cells, resulting in cell cycle arrest and the inhibition of cell proliferation (Brozik et al., 2006; Rangatia and Bonnet, 2006; Morceau et al., 2008).