KEGG analysis in the BaF3-T315 cells showed that the chronic myeloid leukemia signaling pathway (genes such as Cdk4, Tgfbr1, Gadd45b, Mdm2, Gadd45g, Polk, Rb1, Ctbp1, and Cdkn2a were enriched) was involved in the I13 treatment (Figure 6C). This evidence concerns the gene RB1 and chronic myelogenous leukemia, BCR-ABL1 positive.