In the TCGA, compared to normal tissues, 17 genes were differentially expressed in HCC, including ATP7A, DLD, DLAT, DLST, SLC31A1, FDX1, LIPT1, LIAS, LIPT2, PDHA1, NFE2L2, NLRP3, GLS, MTF1, CDKN2A, DBT, and PDHB (Figure 1(a)). The gene discussed is PDHA1; the disease is hepatocellular carcinoma.