The results of GSVA revealed that low-risk group patients showed elevated expression levels of multiple metabolism pathways, like arginine and proline, phenylalanine, glycine, serine, and threonine, and high-risk group patients harbored upregulated expression levels of multiple cell cycle and tumorigeneses pathways, such as bladder cancer, notch signaling pathway, p53 signaling pathway, renal cell carcinoma, cell cycle, and DNA replication (Figure 11(c)). This evidence concerns the gene TP53 and hereditary clear cell renal cell carcinoma.