S100A8 and Helicobacter pylori infectious disease: Several studies have confirmed that CagA plays an indispensable role in the pathogenesis of H. pylori (Franco et al., 2008), so in this paper, the critical signaling pathways induced by CagA are used as the main stem to comb through the relevant studies on the pathogenesis of this protein, which further clarifies the pathogenesis of CagA-positive H. pylori and provides new ideas for clinical blockade of H. pylori infection and treatment of GC.