However, when the signaling pathway is closed, the activated YAP enters the nucleus in the presence of transcription factors TEADs to induce the expression of oncoproteins such as connective tissue growth factor (CTGF) and cysteine-rich angiogenic inducer 61 (CYR61), which further promoting cancer development (Moroishi et al., 2015; Li et al., 2017b; Li et al., 2018). This evidence concerns the gene CCN2 and cancer.