The molecular dynamics simulation of SHP2 confirmed that the binding affinity of EPIYA-D to the N-SH2 domain of SHP2 is more potent than that of EPIYA-C, which explains that part of the reason why the incidence of GC in East Asian countries is much higher than that in western countries is due to the difference of CagA phosphorylation sites on both sides (Hatakeyama, 2004; Wang et al., 2021). The gene discussed is PTPN11; the disease is gastric cancer.