So CagA regulates the interaction with PI3K through the A/T polymorphism of B-TMP, which regulates the activity of the oncogenic-related PI3K/Akt signaling pathway and enhances the risk of GC (Huang et al., 2008; Yong et al., 2015; Zhang et al., 2015). The gene discussed is AKT1; the disease is gastric cancer.