In this study, we outlined the involvement of glucose metabolism in several viral infections (Figure 1) (such as lactate produced by glycolysis playing a major role in HBV immune escape; HBP-mediated O-GlcNAcylation controls IRF5 function during IAV infection, emphasizing the glucose metabolism role in IAV-induced cytokine storm; targeting the mitochondrial ROS/HIF-1a/glycolysis axis can prevent “cytokine storm” in COVID-19 disease). The gene discussed is HIF1A; the disease is viral infectious disease.