IRF5 and viral infectious disease: In this study, we outlined the involvement of glucose metabolism in several viral infections (Figure 1) (such as lactate produced by glycolysis playing a major role in HBV immune escape; HBP-mediated O-GlcNAcylation controls IRF5 function during IAV infection, emphasizing the glucose metabolism role in IAV-induced cytokine storm; targeting the mitochondrial ROS/HIF-1a/glycolysis axis can prevent “cytokine storm” in COVID-19 disease).