CYP24A1 and acute myeloid leukemia: Serum level of Cytochrome P450 24A1, which is a subfamily of Cytochrome P450 enzymes, was significantly lower in Test subjects (subjects consuming Tramadol and Alcohol combination) (0.90±0.06; p=0.01), and significantly threefold higher in subjects with AML (5.16±0.5; p=0.000), when compared with values of non-drug users that served as normal control (1.27±0.07).