PROS1 and viral infectious disease: A typical side effect of HIV-1 infection, HIV-associated FSGS responds regularly to anti-retroviral therapy.  Direct viral infection of renal parenchymal cells and/or the toxicity of viral accessory proteins are two likely pathomechanisms.  Patients of African heritage are particularly susceptible to HIV-associated FSGS.  Although the genetic locus or loci causing this susceptibility are still unknown, MALD is an appealing tool to apply in the search.