Among the proteins enriched in the aortic and coronary arteries, EFEMP1, IGFBP2, THBS2, metalloproteinase inhibitor 1 (TIMP1), were shared between both signatures; biglycan (BGN), contactin-4 (CNTN4) and inhibin beta A chain (INHBA) were unique to the MACE signature, while POSTN was unique to HF signature. Here, EFEMP1 is linked to hydrops fetalis.