Furthermore, NLRP3 inflammasome-induced cardiomyocyte death and cardiac remodeling after AMI are aborgated by inhibiting P2X7, which plays an important role in inflammasome formation and caspase-1 activation during AMI, indicating that the NLRP3 inflammasome is a potential target for the prevention of heart failure (80). The gene discussed is CASP1; the disease is heart failure.