Notably, CD36 can be involved in pathological processes associated with Alzheimer's disease and type 2 diabetes by mediating the uptake of amyloid-forming peptides and thereby activating NLRP3, suggesting signaling crosstalk between lysosome-mediated NLRP3 activation and the reaggregation and conversion of soluble ligands (63). The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.