IRF3 and Sepsis: Li et al. found that sepsis and sepsis-induced cardiomyopathy are closely associated with inflammation, cardiomyocyte apoptosis and pyroptosis, and further study suggested that stimulator of interferon genes (STING) promotes phosphorylated interferon regulatory Factor 3 (IRF3) translocation into the nucleus and subsequently increases the expression of NLRP3 in wild-type mice during LPS stimulation (84).