In addition, as compared with the control group (0.78 ± 0.08), the discrimination index of the mice in both the ADAR1 inducer-treated only group (0.15 ± 0.04) or ADAR1 inhibitor-treated only group (0.03 ± 0.08) decreased evidently (both p < 0.0001), which suggest that the breaking of ADAR1 homeostasis leads to non-spatial cognitive impairment. The gene discussed is ADAR; the disease is Cognitive impairment.