Our results suggest that ADAR1 is supposed to act on pri-mRNA or pre-mRNA of miR-874-3p via A-to-I editing, affect the bio-production of mature miR-874-3p, and then impact DARPP-32 expression via RNA interference, which is involved in the mechanism of stress-induced cognitive impairment (Figure 5). This evidence concerns the gene PPP1R1B and Cognitive impairment.