Particularly, KLF2 exerts a regulatory role in tumor progression, such as inhibiting migration and invasion in ccRCC and endometrial cancer (Lu et al., 2021; Wang et al., 2021), regulating angiogenesis in CRC and non-small cell lung cancer (Zeng et al., 2018; Ma et al., 2021), inducing senescence in pancreatic cancer (Yuedi et al., 2020), regulation of maturity of and regulating T reg cells’ maturity in colon cancer (Osman et al., 2021). Here, KLF2 is linked to malignant colon neoplasm.