Previous reports have highlighted the important role of KLF2 in regulating the tumor immune microenvironment (Rabacal et al., 2016; Tang et al., 2017; Osman et al., 2021; Qu et al., 2022), while immunotherapy represents a significant hope for breast cancer treatment (Emens, 2018; Nederlof et al., 2023). Here, KLF2 is linked to breast cancer.