Recent studies have revealed its involvement in the genesis and progression of several cancers, including clear cell renal cell carcinoma (Lu et al., 2021), gastric Cancer (Wang et al., 2022), colorectal cancer (Zeng et al., 2018; Osman et al., 2021), lung cancer (Ma et al., 2021), hepatocellular carcinoma (Qu et al., 2022), etc. Furthermore, recent research has demonstrated that KLF2 functions as a tumor suppressor in breast cancer (Zhu et al., 2022). This evidence concerns the gene KLF2 and neoplasm.