KLF2 and breast cancer: This dataset reports transcriptional changes induced by statin treatment in breast cancer, and we found that KLF2 expression was upregulated in MCF7 (Luminal A subtype), BT474 (Luminal B subtype), SKBR3 (HER2 subtype) and MDA-MB-231 (Basal subtype) cells after atorvastatin treatment compared to control cells.