Control Braak 0-1 (N = 11), and AD patients (Braak 2-4 (N = 12), Braak 5-6 (N = 12)), B103 cells + Aβ42, Elav-GS-GAL4:UAS-AB3-42 and Elav-GS-GAL4; UAS-APP,UAS-BACE1 flies, hAPP(J20) mice brains. This evidence concerns the gene BACE1 and Alzheimer disease.