A deeper level analysis of the clinical and functional correlations with AAb reactivity patterns is presented below for the EYS and the USH2A gene, which are common causes of autosomal recessive RP (ARRP), in the latter case whether with or without hearing loss (Birch et al., 2020; Duncan et al., 2020) and that are also the ongoing object of natural history characterization (NCT03146078, NCT04127006). This evidence concerns the gene USH2A and hearing loss disorder.