TIMP1 and Hepatic fibrosis: In a mouse model of liver fibrosis, H Yoshiji found that TIMP-1 overexpression resulted in more severe fibrosis in a mouse liver fibrosis model, but had no significant effect on collagen synthesis (Yoshiji et al., 2000), whereas an increase in fibrosis was observed in mice whose TIMP-1 gene had been knocked out (Timp-1−/− mice) (Wang et al., 2011).