To date, four mouse strains (Cx43I130T/+ (Kalcheva et al., 2007), Cx43Jrt(G60S)/+ (Flenniken et al., 2005), Cx43G138R/+ (Dobrowolski et al., 2008) and Cx43K258Stop/- (Pacheco-Costa et al., 2015; Moorer et al., 2017)) with missense point mutations in one allele of the Cx43 gene are generated to mimic the phenotypes of ODDD. The gene discussed is GJA1; the disease is oculodentodigital dysplasia.