Based on the mRNA levels in lung adenocarcinoma tissues, we calculated the IC50 of various chemotherapeutic agents for lung adenocarcinoma patients in different SUMOylation score groups using the pRRophetic package and found that the group with low SUMOylation score was more sensitive to AKT-inhibitor-VIII, bexarotene, erlotinib, GDC0941, MK-2206, among others than that with high SUMOylation score (Figure 8A). Here, AKT1 is linked to lung adenocarcinoma.