We investigated the role of 33 SUMOylation-modified regulatory genes in lung adenocarcinoma, namely, SUMO isoforms (SUMO1, SUMO2, SUMO3, SUMO4), SUMO-Activating Enzyme (SAE1, UBA2), SUMO-Conjugating Enzyme (UBE2I), SUMO E3 Ligases (BCL11A, CAPN3, CBX4, HDAC4, HDAC7, MUL1, NSMCE2, PIAS1, PIAS2, PIAS3, PIAS4, RANBP2, RANGAP1, RNF212, RWDD3, TOPORS, TRIM27, TRIM28, ZMIZ1), SUMO proteases (HINT1, SENP1, SENP2, SENP3, SENP6, SENP5, SENP7, USPL1). This evidence concerns the gene PIAS2 and lung adenocarcinoma.