We found that there were significant differences in GSVA scores of Hallmark gene sets consistent with SUMO-C1 and SUMO-C2 (Figure 3G), and SUMO-C2 were mainly enriched in biological pathways related to the cell cycle, glucose metabolism, and genetic material replication and repair, such as G2M checkpoint, E2F targets, DNA repair, Glycolysis, and PI3K-AKT-mTOR signaling pathways and was highly active in biological processes related to cancer progression such as hypoxia, angiogenesis, and epithelial-mesenchymal transition (Supplementary Figure S2C). Here, AKT1 is linked to cancer.