Moreover, a Philadelphia case–control study in the United States analyzed maternal serum samples that were collected during various prenatal visits or at birth and found that elevated levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were associated with the diagnosis of a psychiatric disorder (i.e., schizophrenia, schizoaffective disorder, and major depression or bipolar disorder with psychosis) decades later in adult offspring (Allswede et al., 2020). This evidence concerns the gene TNF and psychotic disorder.