Therefore, low expression of the genes of the ECM interaction pathway can result in impairment in post-stimulus insulin signaling, which can lead to the development of insulin resistance and type 2 diabetes mellitus (Lin et al., 2009; Waite and Eickholt, 2010; Alan et al., 2013; Tam et al., 2014; Tam et al., 2017; Ahmad et al., 2018; Ahmad et al., 2020). The gene discussed is INS; the disease is diabetes mellitus.