INS and obesity due to melanocortin 4 receptor deficiency: Individuals with overweight or obesity, defined as body mass index (BMI) ≥25 and ≥30 kg⋅m2, respectively, are at higher risk of impaired metabolic homeostasis, reduced insulin sensitivity (Krogh-Madsen et al., 2010) and postprandial lipid metabolism (Booth et al., 2012), which can be contributed by physical inactivity (WHO, 2021).