Although presynaptic CaV2 channels may drive the release of CGRP associated with migraine, high voltage activated and typical postsynaptic CaV1 channels and low voltage activated CaV3 channels have also been found to regulate CGRP release in the trigeminal ganglion, which can be proved by drug blocking experiments (Amrutkar et al., 2011). The gene discussed is CAV2; the disease is migraine disorder.