TRPM2 and gestational trophoblastic neoplasm: GTN-mediated increases of pain intensity, apoptosis, death, cytosolic ROS, mitochondrial ROS, caspase-3, caspase-9, cytosolic Ca2+ levels, and cytokine generations (TNF-α, IL-1β, and IL-6) in the TG of transient receptor potential melastatin 2 (TRPM2) wild-type mouse were further increased by the TRPM2 activation (Yazğan and Nazıroğlu, 2021).