CaV2.1 channels are calcium channels located in the presynaptic membrane and play an important role in communicating between neurons by controlling neurotransmitter release, while presynaptic Cav2 channels might be expected to drive CGRP release associated with migraine, high-voltage-activated and canonical postsynaptic Cav1 channels and low-voltage-activated Cav3 channels have both been found to regulate CGRP release in the trigeminal ganglion. This evidence concerns the gene CAV3 and migraine disorder.