Stimulation of primary cultured trigeminal ganglion cells with capsaicin can mimic migraine attacks in vitro (Wang et al., 2016), and studies have revealed transcriptional upregulation of cytochrome c oxidase subunit IV, Mic60/Mitofilin, and VDAC1, which implies induction of mitochondrial biogenesis to compensate for the loss of mitochondria (Shibata et al., 2020). Here, IMMT is linked to migraine disorder.