MKI67 and neoplasm: Sensitive to additional effects than single-shell dMRI (e.g., diffusion restrictions due to membranes). Suitable for state-of-the-art fiber tractography methods to resolve crossing- and kissing fibers and account for partial volume effects; DKI metrics can be used to grade tumor tissue and predict Ki-67 expression; Detect residual diffusion restriction effects and residual tumor tissue.