PCSK9 and cardiovascular disorder: Considering the cholesterol level is closely related to the risk of cardiovascular disease, many lipid-lowering agents have been in clinical use, such as statins, bile acid sequestrants, ezetimibe, fibrates, omega-3 fatty acids, niacin, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and dietary supplements (Zivkovic et al., 2023).