In a subsequent study, we identified that a substantial proportion of the patients classified as non-M showed a lipidomic profile comparable to that observed in mice deficient in LDL receptor fed a high-fat diet (Ldlr-KO/HFD) [81], which is a mouse model of NASH showing increased VLDL secretion [82]. Here, LDLR is linked to metabolic dysfunction-associated steatohepatitis.