Analysis of the association of four of the major known NAFLD genetic risk factors (HSD17B13, MBOAT7, PNPLA3, and TM6SF2) with the three NAFLD subtypes showed that only the I148M PNPLA3 variant was significantly overrepresented in NAFLD patients with subtypes B and C [83]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.