The comparison of the serum lipidome of this cohort of patients with NAFLD with the lipidomic signatures of four mouse models of NASH (Mat1a-KO, Mttp-KO, Tm6sf2-KO, and MCD diet) presenting reduced VLDL-TG SR and that of the Ldlr-KO/HFD mouse model resulted in the identification of three major metabolic subtypes (Figure 2) [83]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.