However, in bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), breast invasive carcinoma (BRCA), kidney renal clear cell carcinoma (KIRC), pheochromocytoma and paraganglioma (PCPG), rectum adenocarcinoma (READ), prostate adenocarcinoma (PRAD), and thyroid carcinoma (THCA), the expression of DLD was lower compared with that the corresponding control tissues (Fig. 1A). Here, DLD is linked to invasive breast carcinoma.