Although previous meta-analyses have found that the VDR gene polymorphisms could increase the susceptibility to essential hypertension (EH) (Nunes et al., 2020; Zhu et al., 2019), and the VDR gene polymorphisms were reported to be associated with plasma renin activity (Vaidya et al., 2011), the relationship between the VDR gene polymorphisms and the risk of HDP remains controversial in current studies. The gene discussed is VDR; the disease is essential hypertension.