Evidence for the association of the VDR gene polymorphisms with common risk factors for HDP has been reported in previous studies, such as obesity (Chen et al., 2019), GDM (Zeng et al., 2022), hypertension susceptibility (Zhu et al., 2019), chronic kidney disease (CKD) susceptibility (Santoro et al., 2015), etc. Furthermore, the VDR gene polymorphisms might be involved in target organ damage in hypertensive patients (Kulah et al., 2006). This evidence concerns the gene VDR and obesity due to melanocortin 4 receptor deficiency.