APOE and coronary artery disorder: ApoE alleles, especially ɛ4, are among the candidate risk factors that are most likely associated with the risk of CAD in patients with T2DM, and rs157582 in the TOMM40-ApoE region shows a significant association with T2DM (p = 2.8×10−9) (Gao et al., 2021a; Gao et al., 2021b; Larifla et al., 2017; Cook & Morris, 2016a).