According to several studies, both the ApoE ɛ 2 and ɛ4 alleles have been linked to T2DM, and the ApoE ɛ4 allele is an independent risk factor for T2DM and cardiovascular disease, including coronary artery disease (Alagarsamy, Jaeschke & Hui, 2022a; Eichner et al., 2002). The gene discussed is APOE; the disease is type 2 diabetes mellitus.