The TOMM40- ApoE region was found to be positively related to T2DM in a recent multi-ethnic Genome-wide association study (GWAS) (Cook & Morris, 2016), and this association was effectively replicated in various cohorts, including Asians (Long et al., 2019; El-Lebedy, Raslan & Mohammed, 2016). The gene discussed is APOE; the disease is type 2 diabetes mellitus.