We searched the public DIAGRAM type 2 diabetes GWAS data and found that the SNP in the ApoE locus was significantly associated with T2DM in European ancestry, with rs429358 as the leading SNP (p = 1.4 ×10−10, beta = 0.12, number of T2DM cases = 26,676, number of controls = 132,532) (Fig. 3) (Morris et al., 2012). This evidence concerns the gene APOE and type 2 diabetes mellitus.