Overall, various factors, including age, sex, ethnicity, alcohol use, dietary fat, drug therapy, gene-gene and gene-environment interactions, pathogenesis of diabetic dyslipidemia, various complications of diabetes in the study participants, and the number of participants, can explain the inconsistent findings among ApoE polymorphisms and T2DM and serum lipids. The gene discussed is APOE; the disease is type 2 diabetes mellitus.