However, these treatment approaches have some adverse effects, unlike GnRH antagonist, which inhibits gonadotropin secretion without inducing flare effect while competing with natural GnRH. In addition to the therapeutic use of GnRH analogs, the regulation of GnRH pulsatile release provides new research prospects for the diagnosis and treatment of female reproductive system disorders and their resulting complications, such as tumor development and iatrogenic diseases. This evidence concerns the gene GNRH1 and female reproductive system disorder.