However, another study has reported that the number of ILC1 and the production of IFN-γ were significantly suppressed in CRC, and importantly, ILC3s differentiated toward another IL-10-producing regulatory ILCs (ILCregs) under the regulation of TGF-β signaling, ultimately promoting colon tumor progression (146). This evidence concerns the gene TGFB1 and colorectal carcinoma.