HIF1A and neoplasm: Tissue inhibitor matrix metalloproteinase-1 (both exogenous and endogenous) leads to the upregulation of exosomal miR-210 in the CD63/phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (AKT)/HIF-1-dependent pathway in lung adenocarcinoma cells, promotes tube-forming activity in human umbilical vein endothelial cells, and leads to increased tumor angiogenesis (90).