MAPT and early-onset autosomal dominant Alzheimer disease: Another study that evaluated microglia activation in aged wild type mice, and genetic mouse models of Aβ and tau pathologies, using 18-kDA translocator protein positron emission-tomography (TSPO-PET) reported detecting a higher signal for female microglia in both the wildtype and Aβ mice, but not in the tau model of Alzheimer’s disease (161).