Another study that evaluated microglia activation in aged wild type mice, and genetic mouse models of Aβ and tau pathologies, using 18-kDA translocator protein positron emission-tomography (TSPO-PET) reported detecting a higher signal for female microglia in both the wildtype and Aβ mice, but not in the tau model of Alzheimer’s disease (161). This evidence concerns the gene MAPT and Alzheimer disease.