While CD4+ T cells are the major players in EAE pathology and MS initiation, CD8+ T cells feature more prominently in WM and intracortical lesions in MS (47, 100) and viruses such as Epstein Barr Virus (EBV), which evoke CD8+ T cell immunity, have been implicated in MS initiation (101). Here, CD4 is linked to myeloid sarcoma.