In addition, the TNF-α levels in both the serum and multiple organs are significantly increased in CCl4-cirrhotic rats with compared with those without GBT (109) Similarly, patients with advanced cirrhosis with ascites exhibit elevated blood TNF-α levels along with an increase in the local production of TNF-α in the MLNs, which correlates with GBT (110). The gene discussed is TNF; the disease is Cirrhosis.