In experimental cirrhosis, FXR activation by obeticholic acid (OCA) increases ileal protein expression of the main TJ proteins and AMP secretion (10, 13), influences intestinal epithelial cell proliferation and apoptosis (146), and exerts potent antiinflammatory actions in the intestine, stabilizing epithelial integrity (10). This evidence concerns the gene NR1H4 and Cirrhosis.