The pooled analysis of these results ultimately revealed that TNF-α rs361525 was linked to LC risk in the ALC and HBV subgroups, while IFN-γ rs2430561 was more strongly related to the risk of LC in HBV patients and Asian populations, potentially providing a valuable foundation for future efforts to prevent, diagnose, and treat LC in its earlier stages. The gene discussed is TNF; the disease is laryngotracheoesophageal cleft.