TNFRSF1A and primary biliary cholangitis: The hub gene TNFRSF1A may offer value as a marker of PBC (58), and one GWAS study of 1,840 cases and 5,163 controls identified the TNFRSF1A rs1800693 SNP as a PBC-related risk factor (OR=1.23, 95%CI=1.14-1.33) (59).