IFN-γ is another pro-inflammatory cytokine that can influence hematopoietic stem cell development at baseline and serves as a major pathogenic factor associated with various forms of hematopoiesis-related disease stats such as hemophagocytic lymphohistiocytosis, aplastic anemia, and LC (19). The gene discussed is IFNG; the disease is laryngotracheoesophageal cleft.