Previous studies revealed that ErbB signaling regulates cell proliferation, migration, differentiation, apoptosis, and motility by mediating the phosphoinositide 3-kinase/Akt, Janus kinase/signal transducer and activator of transcription, and mitogen-activated protein kinase signaling pathways, with activation of the latter pathway in IDD possibly leading to apoptosis of annulus fibrosus and NP cells (34, 35). Here, WNK2 is linked to intervertebral disk degenerative disorder.