Valve lesion was positively associated with aSM IgM (Fisher test p = 0.039), APS nephropathy was positively associated with aβ2GpI IgG/M (Fisher test p = 0.019), and aPC IgG (OR 3.797, 95% CI 1.076-13.392), livedo reticularis was positively associated with aPE IgM (OR 15.391, 95% CI 1.392-1370.195), while epilepsy was negatively associated with aPI IgM (OR 0.204, 95% CI 0.052-0.806). The gene discussed is CD40LG; the disease is Livedo reticularis.