Golden classification criteria for APS (Sydney criteria) required the presence of at least one clinical criteria as well as one of the laboratory criteria including lupus anticoagulant (LA), medium to high level of anti-cardiolipin (aCL), anti-β2 glycoprotein-I (aβ2GPI) immunoglobulin isotype G (IgG) or M (IgM) positivity at 12 weeks apart (1). This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.