Furthermore, loss-of-function mutations in the proteins GLA, GBA, PPT1, ASAH1, GALC, HEXA, HEXB and FUCA1 are associated with lysosomal storage disorders, including Fabry’s disease, Gaucher’s disease, Neuronal ceroids lipofuscinosis, Krabbe’s disease, Sandhoff and Tay Sachs disease (62). The gene discussed is GBA1; the disease is infantile neuronal ceroid lipofuscinosis.