Moreover, 10 hub genes including CXCL8, IL18, CXCL10, CD8A, IL7, PTPRC, CCL5, IL7R, CXCL9 and CCL2 were identified from PPI network of 98 HFIGs and the expressions of these hub genes were positively correlated with the degree of liver inflammation and fibrosis. This evidence concerns the gene IL18 and Hepatitis.