(26) found that CXCL8 was highly expressed in serum and liver tissues of patients with chronic liver disease, and its expression was positively correlated with inflammatory cytokines and fibrosis markers in the liver, and CXCL8 recruitted and activated the hepatic macrophages via CXCR1 in human non-cholestatic cirrhosis. The gene discussed is CXCR1; the disease is primary biliary cholangitis.