To illustrate the role of lactate level in tumor, we first collected key LAGs from GO gensets (GO_LACTATE_METABOLIC_PROCESS; GO_LACTATE_TRANSPORT), including HIF1A, LDHA, LDHB, PFKFB2, SLC16A1, SLC16A3, SLC16A7, SLC16A8, and UEVLD. This evidence concerns the gene PFKFB2 and neoplasm.