In bulk RNA-seq analysis, cluster 1 samples scored higher in glycolysis, innate immunity, priming activation, T cells, IFNG response, inhibitory molecules, marrow-derived suppressor cells, and recognition of tumor cells (GBM meta cohort in Figure 5A and Supplementary Figure 9A, TCGA GBM array cohort in Supplementary Figures 7A, 9B, Xiangya cohort in Supplementary Figures 8A, 9C). Here, IFNG is linked to neoplasm.