Among most of these tumor types, a negative correlation between gene methylation and mRNA expression was revealed by calculating the Spearman correlation, including HIF1A, SLC16A1, UEVLD, SLC16A8, PFKFB2, LDHB, and SLC16A3 (Supplementary Figures 1A, B). The gene discussed is SLC16A1; the disease is neoplasm.