For example, charged MVB protein 2B (CHMP2B) is a subunit of ESCRT and mutation of CHMP2B could lead to the pathogenesis of amyotrophic lateral sclerosis (Parkinson et al., 2006) and frontotemporal dementia (Skibinski et al., 2005). The gene discussed is CHMP2B; the disease is frontotemporal dementia.