Further evidence that suggested the participation of autophagy in depression was the effect of antidepressants on the co-chaperone FKBP51, a regulator of the NR3C1-glucocorticoid receptor involved in the stress response and inhibitor of Akt1 that in turn regulates the activity of beclin 1 in the autophagy signaling pathway (Gassen et al., 2015; Jia and Le, 2015). Here, NR3C1 is linked to major depressive disorder.