For example, charged MVB protein 2B (CHMP2B) is a subunit of ESCRT and mutation of CHMP2B could lead to the pathogenesis of amyotrophic lateral sclerosis (Parkinson et al., 2006) and frontotemporal dementia (Skibinski et al., 2005). Here, CHMP2B is linked to amyotrophic lateral sclerosis.