OPTN and amyotrophic lateral sclerosis: Other genes associated with ALS include fused in sarcoma (FUS), sequestosome1 (SQSTM1 also known as p62), optineurin (OPTN), TANK binding kinase 1 (TBK1), VAMP-associated protein B (VAPB), valosin-containing protein (VCP), ubiquilin 2 (UBQLN2), alsin, charged multivesicular body protein 2B (CHMP2B), dynactin (DCTN), profilin 1 (PFN1), factor-induced gene 4, and a hexanucleotide repeat expansion in the gene C9orf72 (Guo et al., 2018; Nguyen et al., 2019).