MAPT and Alzheimer disease: For instance, recent studies have shown the potential therapeutic properties of autophagy inducers such as bromo-protopine, a protopine derivative that stimulates CMA and reduces the presence of pathological tau in AD models (Sreenivasmurthy et al., 2022) and klotho, a single-pass transmembrane protein in the brain, that induces autophagy leading to increased autophagy mediated clearance of amyloid-β in AD models (Fung et al., 2022).