Finally, in the AD mice model, We tested all the candidate genes and found that a total of five genes were confirmed with consistent differences as follows: epidermal growth factor receptor pathway substrate 8 (EPS8), zinc finger MIZ-domain containing 1 (ZMIZ1), telomere maintenance 2 gene (TELO2), protein kinase C zeta (PRKCZ), and mannosidase alpha class 1B member 1 (Man1b1) (Figure 6 and Table 1). Here, MAN1B1 is linked to Alzheimer disease.