The perturbation of GLYAT induces harmful disruption to CoA homeostasis (Badenhorst et al., 2013), musculoskeletal development (Badenhorst et al., 2013), and obesity-related metabolic disturbances (Fedry et al., 2016; Alves et al., 2019), suggesting that acetylglycine plays a role in the development of obesity-related diseases. This evidence concerns the gene GLYAT and obesity due to melanocortin 4 receptor deficiency.