NFKB1 and neoplasm: In TNBC tumor tissue, miR-301b was shown to be upregulated, and Song et al. discovered that it directly bound to the 3′-UTR of the CYLD lysine 63 diquinase mRNA to activate NF-kB p65 and prevent 5-FU from inducing tumor cell apoptosis (Song et al., 2018).