SPATA20 and Infertility: These included ICM-related genes, such as TRIM36 (which has been linked to chromosomal instability when overexpressed) (Miyajima et al., 2009) and SPATA20 (which is impaired in infertile patients) (Omolaoye et al., 2022); as well as TE-related genes such as NELL1 (which plays a role in protein modification and cellular metabolism in human preimplantation embryos) (Sun et al., 2022).