Thisis remarkable considering that proteins in this pathway are majordrug targets in cancer and that FLuc-based reporters have been reportedfor Akt, c-Met, EGFR, and ATM.15,16,42 The development of ERK KiMBI thus also fills a previously unmetneed for noninvasive reporting of Ras-ERK pathway activity in mammals. The gene discussed is AKT1; the disease is cancer.