During pathogenic infection,type I interferon (INF) controls innate and adaptive immune responsesand induces host defense mechanisms by activating the JAK-STAT signalingpathway, leading to interferon-stimulated gene (ISG) responses.26 Mpro of different coronaviruses,including porcine deltacoronavirus,27,28 porcine epidemicdiarrhea virus,29 and feline infectiousperitonitis virus,30 disrupts the INF-inducedpathway by cleaving NF-κB essential modulator (NEMO). The gene discussed is CBLIF; the disease is infection.