Pabloset al. in a recent study demonstrated that the cleavage event at Q158resulted in a loss of hemagglutination activity of Gal-8, which itpossesses due to its bivalent carbohydrate binding capacity.32 Here we aimed to determine if Gal-8 proteolysisby Mpro had an effect on its immune regulatory activityand cytokines secretion, given the fact that cytokines play essentialroles in acute and chronic viral infections which can have beneficialeffects during viral clearance. The gene discussed is LGALS8; the disease is viral infectious disease.