CLU and Alzheimer disease: In addition, given the role that lipid metabolism plays in AD (Zhu et al., 2019; Kao et al., 2020; Paasila et al., 2021; Turri et al., 2022), TREM2 function as a lipid metabolism regulator (Wang et al., 2015; Nugent et al., 2020; Li et al., 2022), and CLU binding lipids and cholesterol to influence their trafficking (Matukumalli et al., 2017; Foster et al., 2019), the interaction between TREM2 and CLU should be further explored as it could have a great impact on AD pathogenesis.