Both sCLU and nCLU are upregulated in response to stress (Nizard et al., 2007) and inflammation, and CLU and CLU mRNA is altered in neurodegenerative disorders (Grewal et al., 1999; Sasaki et al., 2002; Ingram et al., 2014; Labadorf et al., 2015; Das Gupta et al., 2019; Yuste-Checa et al., 2022), including AD (Calero et al., 2005; Zhou et al., 2014; Bettens et al., 2015; Foster et al., 2019; Jackson et al., 2019). The gene discussed is CLU; the disease is Alzheimer disease.