Studies have shown that CLU expression is upregulated in degenerative conditions, such as AD (Calero et al., 2005; Nuutinen et al., 2009), due to cellular and oxidative stress or dysregulation of specific signaling pathways (Wong et al., 1994; Gutacker et al., 1999; Schepeler et al., 2007; Trougakos and Gonos, 2009). The gene discussed is CLU; the disease is Alzheimer disease.