This includes Neat1 that plays a key role in the modulation of neuronal activity and hippocampal-dependent memory formation in mice (Barry et al., 2017; Butler et al., 2019) and has been implicated in Alzheimer’s disease (Riva et al., 2016; Yang et al., 2017; Wu et al., 2019). The gene discussed is NEAT1; the disease is early-onset autosomal dominant Alzheimer disease.