Notably, AF events were registered in four transcripts coding for histone H3-K9 methylation components (Kdm4a, Kdm4c, Mecp2, Suv39h2), corroborating a potential role in chromatin remodeling during aging (Keenan et al., 2020); seven transcripts associated with the regulation of the Notch signaling pathway (e.g., Dkl2, Hes1) which plays an important role in aging (Balistreri et al., 2016); and seven transcripts encoding ribosomal proteins, whose expression is translationally repressed in aged animals (cytoplasmic Rpl5, Rpl7, Rpl18a, Rpl37rt; and mitochondrial Mrpl23, Mrpl30, and Mrps5). Here, HES1 is linked to atrial fibrillation.