For instance, genes encoding proteins acting in calcium mediated signaling, which is consistent with disruption of age-related changes in long-term potentiation and deficits in hippocampal-dependent behavioral tasks in the aging mice (Pereda et al., 2019); and ribonucleoprotein (RNP) granules, that have been involved in the development of Alzheimer’s disease and frontotemporal dementia (Wolozin and Ivanov, 2019; Desai and Bandopadhyay, 2020). The gene discussed is RNPC3; the disease is early-onset autosomal dominant Alzheimer disease.