MAPT and Alzheimer disease: Additionally, pathological AD hallmarks have been observed in the retina, including neuron loss caused by hyperphosphorylation of tau protein (p-tau), Aβ plaques, and neurofibrillary tangles (Ho et al., 2012; Cabrera DeBuc et al., 2017; Golzan et al., 2017; Koronyo et al., 2017).