Additionally, genes associated with ruptured aortic aneurysms in aortic wall tissue were significantly enriched in pathways related to allograft rejection, complement cascade, inflammatory response, interferon-gamma response, tumor necrosis factor alpha (TNF-α) signaling via NF-κB, and IL6-JAK-STAT3 signaling (|NES| ≥ 2.00, P < 0.05, Figure 1H). Here, STAT3 is linked to aortic aneurysm.