As of now, there is no clear report on the internal mechanism of CD73 increase in Treg cells of patients with hepatitis B, but some studies have shown that CD73 is an important regulator of Treg cells to restrain intracellular environmental inflammation, and the author conjectures that it may be related to the independent expression of CD73 in Treg cells under inflammatory environment and the immunosuppressant effect mediated by adenosine (24). Here, NT5E is linked to hepatitis B virus infection.