Acetaldehyde induces activation of CD73 in HSC, and induces the increased expression of pro-fibrotic cytokines TGF-β, α-SMA and type I and III collagen, promoting the generation of liver fibrosis.Activated HSC can up-regulate CD73 expression by specific SP1 and SMAD promoter elements. The gene discussed is NT5E; the disease is Hepatic fibrosis.