CD73-deficient mice are resistant to the development of liver fibrosis and can protect liver cells from the risk of inducing cirrhosis by CCl4 and thioacetamide (TAA).After CD73 deletion, adenosine production is reduced, leading to p2 receptor-mediated HSC activation proliferation and collagen expression decrease, and inhibiting the production of liver fibrosis.Inhibition of CD73 can promote HSC apoptosis, alleviate alcohol-related liver fibrosis.A2A adenosine receptor deficient mice were also protected from liver fibrosis due to the blocking of adenosine pathway. Here, ADORA2A is linked to Cirrhosis.