CD73-deficient mice relatively exhibite less liver cell dilatation and steatosis, and the incidence of fatty liver is significantly reduced.Blocking the adenosine pathway in CD73 knockout mice can reduce adenosine-mediated extracellular matrix deposition through hepatic stellate cells, thereby protecting mice from ethanol-induced fatty liver.Blocking the expression of CD73, A1 or A2B receptors in liver can effectively reduce the accumulation of liver lipids caused by alcohol and delay the course of disease. Here, NT5E is linked to fatty liver disease.