CD73 enhances intracellular AMP by inducing immune escape in TME, initiates a variety of downstream signaling pathways, and inhibits antitumor response.CD73 can induce the increase of tumor vascular endothelial growth factor (VEGF), promote angiogenesis and help tumor cells survive.CD73 may be related to inflammatory signaling in liver cancer, stimulating inflammation through adenosine receptor signaling pathway and providing a suitable pro-inflammatory environment for tumor cells to survive. The gene discussed is NT5E; the disease is liver cancer.